Iron deposits are typical features of endometrial lesions and increased concentrations are found in the pelvic cavity of patients with the disease. The researchers, led by Professor Jacques Donnez, head of the Department of Gynaecology, hypothesised that iron overload might be involved in the origin and development of endometriosis. The iron could originate from the breakdown of erythrocytes (oxygen-bearing red blood cells) carried into the pelvic cavity by retrograde menstruation (menstrual blood flowing back into the fallopian tubes).
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