Prophylactic bilateral oophorectomy before women are 45 results in an increased risk of all-cause mortality, especially if they are not given replacement estrogen, found researchers here.
Overall, for women of any age, a prophylactic bilateral oophorectomy appeared to make little difference in the risk of death, according to Walter Rocca, M.D., of the Mayo Clinic College of Medicine.
But removing the ovaries before the age of 45 resulted in a 67% increase in the risk of death from any cause, compared with a population-based group, with much of the increase coming among women who were not given replacement estrogen, Dr. Rocca and colleagues reported in the Sept. 14 online issue of Lancet Oncology.
The finding was based on a cohort study involving 2,365 women who underwent either a unilateral or bilateral oophorectomy in Olmstead County, Minn., from 1950 through 1987. Olmstead County is home to the Mayo Clinic.
Popularity: 1% [?]
Post a Comment