Possible new directions for the treatment of endometriosis, a painful condition associated with infertility that affects up to 15% of women of reproductive age, will be outlined in the presentation of two experimental studies at the 23rd annual conference of the European Society of Human Reproduction and Embryology (Tuesday July 3). Both concern targeting angiogenesis — the formation of new blood vessels — which is encourages endometriosis by providing a rich blood supply.
The scientists found that the blood vessel formation in the lesions was significantly decreased. “The percentage of new blood vessels in the two treatment groups was reduced in comparison to the control group, and we also found that the percentage of old blood vessels in these groups were higher”, says Dr. Novella-Maestre. “The total number of the blood vessels was not dissimilar in the treatment and control groups, but the ratio of new/old blood vessels, the numbers of cells growing in the endometrial area, and the area lesions were totally different, suggesting that there was inhibition of blood vessel replacement in the treatment group.”
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